SLU-PP-332 5mg

What Is SLU-PP-332?

SLU-PP-332 is a synthetic small-molecule pan-agonist of the estrogen-related receptor (ERR) family, studied in preclinical research involving metabolic and mitochondrial signaling. Chemically, it’s 4-hydroxy-N-[(E)-naphthalen-2-ylmethylideneamino]benzamide — a nuclear receptor ligand, not a peptide, which sets it structurally apart from most other compounds in this catalog.

SLU-PP-332 activates ERRα, ERRβ, and ERRγ, which are nuclear receptors involved in transcriptional regulation of genes associated with mitochondrial function, fatty-acid oxidation, and energy metabolism. This receptor-to-gene-program relationship is the basis for nearly all research interest in the compound.

Why SLU-PP-332 Is Called an “Exercise Mimetic”

In mouse skeletal-muscle studies, SLU-PP-332 activates a gene-expression program that substantially overlaps with the one activated by endurance exercise — which is why it’s often described in the literature as an exercise mimetic. This term describes a specific transcriptional overlap observed in controlled preclinical models. It does not mean the compound has been shown to replace exercise, and no human clinical trials of SLU-PP-332 exist. All available evidence comes from in vitro and rodent studies.

SLU-PP-332 Research Areas

SLU-PP-332 and ERRα

ERRα is the primary receptor target of SLU-PP-332 and is studied as the principal mediator of its exercise-mimetic effects. Research has focused on ERRα’s role in driving downstream expression of genes tied to mitochondrial density and glucose transport in skeletal muscle.

SLU-PP-332 and Mitochondrial Function

Studies have examined SLU-PP-332’s effect on mitochondrial biogenesis and respiration, looking at how ERR activation influences the number and efficiency of mitochondria within muscle and other metabolically active tissue.

SLU-PP-332 and Fatty-Acid Oxidation

Research has investigated how SLU-PP-332 affects fatty-acid oxidation pathways, examining enzyme activity involved in converting stored fat into cellular energy under ERR-driven transcriptional programs.

SLU-PP-332 and Skeletal Muscle Research

Preclinical work has studied fiber-type shifting in skeletal muscle following SLU-PP-332 administration, focusing on transitions toward oxidative fiber programs associated with endurance-trained tissue.

SLU-PP-332 and Metabolic-Disease Models

SLU-PP-332 has been studied in diet-induced obesity and metabolic-syndrome mouse models, examining energy expenditure and metabolic markers under ERR pathway activation.

Mechanism of Action

SLU-PP-332 activates all three ERR isoforms, with strongest potency at ERRα, followed by ERRβ and ERRγ. These receptors function as transcription factors controlling genes linked to mitochondrial density, fatty-acid oxidation enzymes, and glucose transport. ERRγ activation has additionally been linked to cardioprotective signaling research in preclinical cardiac models. This receptor-selective activation profile is the basis for studying SLU-PP-332 as a tool for isolating specific components of the exercise-response transcriptional program.

Specifications

Quality note: This lot was tested by MZ Biolabs using HPLC-UV-MS, with a purity result of 98.78%. Identity was independently confirmed by mass spectrometry — measured monoisotopic mass of 290.10 Da against an expected 290.11 Da.

For laboratory research use only. Not for human or animal use. Not intended to diagnose, treat, cure, or prevent any disease.